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Two new monoterpene lactones from Ligularia rumicifolia (J.R.Drumm.) S.W.Liu and their anti-proliferative activities

Author:
Zhang, Jing, Jiang, Wei, Cao, Hong-Jie, Qu, Yanbo, Liao, Zhi-Xin, Liu, Chao, Sun, Jin-Yue
Source:
Phytochemistry letters 2018 v.28 pp. 55-58
ISSN:
1874-3900
Subject:
Ligularia, carboxylic acids, cell lines, chemical constituents of plants, cytotoxicity, ethyl acetate, inhibitory concentration 50, lactones, monoterpenoids, spectroscopy
Abstract:
A phytochemical study of the EtOAc extract of Ligularia rumicifolia (J.R.Drumm.) S.W.Liu led to the isolation of two new monoterpene lactones (1-2) named (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid and (2S,3S,5R)-5-ethyl-2,3-dimethyl-6-oxoterahydro-2H-pyran-2-carboxylic acid methyl ester, along with nine known compounds (3-11). All compounds were isolated from this species for the first time. Their structures were established on the basis of spectroscopic methods. The cytotoxic activity of Compound 2 was weak, with the lowest IC50 value of 80.84 μM against MCF-7 cells. Compound 1 exhibited better anti-proliferative activities against MCF-7, T-24, HepG-2 and SKOV-3 cell lines than Compound 2, with the lowest IC50 value of 66.12 μM against MCF-7 cells.
Agid:
6234936