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Cytotoxic polyketides from endophytic fungus Phoma bellidis harbored in Ttricyrtis maculate

Author:
Wang, Wen-Xuan, Zheng, Mei-Jia, Li, Jing, Feng, Tao, Li, Zheng-Hui, Huang, Rong, Zheng, Yong-Sheng, Sun, Huan, Ai, Hong-Lian, Liu, Ji-Kai
Source:
Phytochemistry letters 2019 v.29 pp. 41-46
ISSN:
1874-3900
Subject:
Phoma, cisplatin, cytotoxicity, endophytes, fermentation, fungi, human cell lines, humans, inhibitory concentration 50, neoplasm cells, nuclear magnetic resonance spectroscopy, polyketides, rice
Abstract:
Four new polyketides, namely bellidisins A-D (1-4), were isolated from rice fermentation extract of endophytic fungus Phoma bellidis, along with three known compounds pinolidoxin (5), 5,6-epoxypinolidoxin (6), and 2-epi-herbarumin II (7). Their structures and absolute configurations were determined by 1D and 2D NMR, HRESIMS and ECD calculation. Their cytotoxicity was evaluated against human cancer cell lines HL-60, A549, SMMC-7721, MCF-7, and SW480. Compound 4 showed significant cytotoxicity on these five cell lines with IC50 value ranged from 3.40 to 15.25 μM, which is stronger than cisplatin (4.86–27.70 μM).
Agid:
6234956