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Morphinandienone and aporphine alkaloids from Corydalis decumbens

Author:
Zhang, Chun-Lei, Huang, Qi-Long, Chen, Juan, Zhao, Fang, Zhang, Fan, Cao, Zheng-Yu
Source:
Phytochemistry letters 2019 v.29 pp. 70-74
ISSN:
1874-3900
Subject:
Corydalis decumbens, alkaloids, chemical constituents of plants, neurons, spectral analysis
Abstract:
Phytochemical examination of Corydalis decumbens has afforded two new morphinandienone alkaloids, namely, (-)-pallidine N-oxide (1) and (-)-salutaridine N-oxide (2), together with one known analogue, (-)-pallidine (3), and three known aporphine alkaloids (4−6). Their structures were elucidated via comprehensive spectroscopic analysis and chemical correlation. This study represents the first isolation of morphinandienone alkaloids from the title plant. All isolates were tested for their activities towards neuronal excitability in primary cultured neocortical neurons.
Agid:
6234965