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A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp.

Author:
Liu, Si-Si, Jiang, Ju-Xing, Huang, Rong, Wang, Ya-Ting, Jiang, Bo-Guang, Zheng, Kai-Xuan, Wu, Shao-Hua
Source:
Phytochemistry letters 2019 v.29 pp. 75-78
ISSN:
1874-3900
Subject:
Aconitum vilmorinianum, Influenza A virus, Phoma, alcohols, antiviral properties, culture media, endophytes, fungi, inhibitory concentration 50, roots, sesquiterpenoids, spectral analysis
Abstract:
A new rare 14-nordrimane-type sesquiterpenoid, named phomanolide (1), together with five known compounds, (–)-6-methoxymellein (2), 7-hydroxy-3, 5-dimethyl-isochromen-1-one (3), norlichexanthone (4), 6-methylsalicylic acid (5), and gentisyl alcohol (6), were obtained from the culture broth of an endophytic fungus Phoma sp. isolated from the roots of Aconitum vilmorinianum. The structure of compound 1 was established based on extensive spectroscopic analysis. Compound 1 was the first example of 14-nordrimane-type sesquiterpene up to now. Compounds 1 and 2 showed antiviral activities against influenza A virus (A/Puerto Rico/8/34, H1N1) with IC50 values of 2.96 ± 0.64 and 20.98 ± 2.66 μg/mL, respectively.
Agid:
6234966