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A systematic review and meta-analysis of randomized controlled trials to evaluating the trend of cytokines to vitamin A supplementation in autoimmune diseases

Harirchian, Mohammad Hossein, Mohammadpour, Zinat, Fatehi, Farzad, Firoozeh, Negar, Bitarafan, Sama
Clinical nutrition 2019 v.38 no.5 pp. 2038-2044
atherosclerosis, autoimmune diseases, blood serum, gene expression, gene expression regulation, interferon-gamma, interleukin-17, meta-analysis, patients, randomized clinical trials, sclerosis, signs and symptoms (animals and humans), systematic review, transforming growth factor beta, vitamin A
Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease.Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines.Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases.Vitamin A supplementation effects on gene expression and may improve serum level of cytokines and clinical signs of autoimmune disease but there is no adequate evidence.