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Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats

Author:
Ghosh, Sumit, Chowdhury, Sayantani, Das, Abhishek Kumar, Sil, Parames C.
Source:
Food and chemical toxicology 2019 v.124 pp. 64-80
ISSN:
0278-6915
Subject:
DNA fragmentation, adverse effects, apoptosis, blood glucose, blood serum, body weight, caspase-12, cytokines, diabetes, enzyme activity, gene expression regulation, histology, inflammation, laboratory animals, males, mitochondria, oxidative stress, rats, streptozotocin, taurine, testes, testosterone, therapeutics, transcription factor NF-kappa B
Abstract:
One of the major consequences of diabetes is reproductive dysfunction but the fundamental mechanisms are still poorly known. The objective of the present study was to explore the beneficial role of taurine against streptozotocin induced testicular dysfunctions in diabetic male Wister rats and understanding the underlying intricate molecular mechanisms. Exposure to streptozotocin (50 mg kg−1 body weight, i.p., once) elevated blood glucose level, induced testicular histological alterations and reduced testis-to-body weight ratio, serum testosterone, testicular markers and activity of antioxidant enzymes. Generation of ER stress (increased expression of calpain-1, caspase-12 and upregulation of CHOP, GRP78 via eIF2α signaling), translocation of NF κB in the nucleus (leading to the upregulation in the levels of inflammatory cytokines), activation of mitochondria dependent apoptotic pathway and DNA fragmentation were revealed from this study. However, administration of taurine at a dose of 100 mg kg−1 body weight for 6 weeks post diabetic induction, successfully ameliorated all these adverse effects. Thus, taurine, as a potential therapeutic agent, may hold promise in preventing oxidative and ER stress mediated diabetic testicular complications in rats.
Agid:
6236104