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Acid-catalyzed synthesis of functionalized arylthio cyclopropane carbaldehydes and ketones

Author:
PorcuThese authors contributed equally to this work., Stefania, Luridiana, Alberto, Martis, Alberto, Frongia, Angelo, Sarais, Giorgia, Aitken, David J., Boddaert, Thomas, Guillot, Regis, Secci, Francesco
Source:
Chemical communications 2018 v.54 no.96 pp. 13547-13550
ISSN:
1364-548X
Subject:
Bronsted acids, chemical reactions, ketones
Abstract:
A general strategy for the synthesis of arylthio cyclopropyl carbaldehydes and ketones via a Brønsted acid catalyzed arylthiol addition/ring contraction reaction sequence has been exploited. The procedure led to a wide panel of cyclopropyl carbaldehydes in generally high yields and with broad substrate scope. Mechanistic aspects and synthetic applications of this procedure were investigated.
Agid:
6240354