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Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Author:
Diniz, Miriely S., Teixeira‐Neto, Francisco J., Gonçalves, Daniele S., Celeita‐Rodríguez, Nathalia, Girotto, Carolina H., Fonseca, Mariana W., Takahira, Regina K.
Source:
Journal of veterinary internal medicine 2018 v.32 no.6 pp. 1927-1933
ISSN:
0891-6640
Subject:
anesthesia, blood, blood coagulation, coagulum, cross-over studies, dogs, firmness, hematocrit, hemorrhage, hemostasis, thromboplastin, veterinary medicine, viscoelasticity
Abstract:
BACKGROUND: Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. OBJECTIVE: Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. ANIMALS: Six healthy English Pointer dogs (19.7‐35.3 kg). METHODS: Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8‐week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs). RESULTS: Buccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa‐angle increased from controls from 0.5 to 4 hours after LRS (CFT, P ≤ 0.0001‐0.02; alpha angle, P = 0.0001‐0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002‐0.01; alpha angle, P = 0.0005‐0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P ≤ 0.0001‐0.01) and TS (P ≤ 0.0001‐0.04). CONCLUSIONS AND CLINICAL RELEVANCE: Tetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum.
Agid:
6241746