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Fuzzy: a genetic marker for warfarin resistance in the Norway rat
- Greaves, J. H., Ayres, Priscilla B.
- Laboratory animals 1985 v.19 no.2 pp. 145-147
- Rattus norvegicus, alleles, backcrossing, genetic markers, laboratory animals, linkage groups, loci, mice, rats, warfarin
- No recombination was observed between fuzzy (fz) and warfarin resistance (Rw ʷ) in 245 rats from a backcross test for linkage. This locates fz very close to Rw in linkage group I. The map position established for fz makes this allele particularly suitable for use in combination with p (pink-eyed dilution) for linkage tests in group I and as a genetic marker for the Rw locus in studies of warfarin resistance. The map position of fz in the rat corresponds to that of fr (frizzy) in the mouse, suggesting homology between these loci in the 2 species.