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Enhanced Bioavailability of EPA From Emulsified Fish Oil Preparations Versus Capsular Triacylglycerol

Susan K. Raatz, LuAnn K. Johnson, Michael R. Bukowski
Lipids 2016 v.51 no.5 pp. 643-651
bioavailability, blood sampling, chylomicrons, cross-over studies, dietary fat, dietary nutrient sources, dietary supplements, emulsions, fatty acid composition, fish oils, gas chromatography, omega-3 fatty acids, phospholipid fatty acids, triacylglycerols, volunteers
For those individuals who are unable to consume adequate long chain omega-3 fatty acids (LCn3) from dietary sources, fish oil supplementation is an attractive alternative Pre-emulsified fish oil supplements, an alternative to capsular triacylglycerol, may enhance the uptake of LCn3 fatty acids it contains. A randomized, Latin-square crossover design was used to compare the effects of four fish oil supplement preparations (Emulsions S, B and N) on phospholipid fatty acid (PLFA) concentrations in ten healthy volunteers compared to oil capsules over 48 h after a single dose and chylomicron fatty acid (CMFA) was evaluated over 8 h. Blood samples were collected at 0, 2, 4, 8, 24 and 48 h and fatty acid concentrations of PLFA and CMFA were determined by gas chromatography and the integrated area under the curve over 40 h (ᵢAUC₀–₄₈) was determined. Emulsion S and Emulsion N promoted increased uptake of EPA into PLFA over 48 h when evaluating by ᵢAUC₀–₄₈ or individual time points of assessment. No differences were observed between supplements in the CMFA concentrations.