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Corticosterone determination in bronchoalveolar lavage fluid and its relationship to free and total plasma corticosterone
- Thomas, Jith, Thomson, Errol M.
- Analytical biochemistry 2019 v.567 pp. 27-29
- corticosterone, immune response, inflammation, lungs, respiratory tract diseases
- Endogenous glucocorticoids modulate airway and lung inflammation in various respiratory diseases and after exposure to airborne contaminants. Although bronchoalveolar lavage fluid (BALF) is commonly used to evaluate the inflammatory and immune response in the lungs, limited information is available on determination of endogenous glucocorticoid levels in BALF. Here we describe a simple method to determine corticosterone in BALF, and evaluate the relationship between BALF and plasma corticosterone.