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A polyvinyl alcohol-coated core-shell magnetic nanoparticle for the extraction of aminoglycoside antibiotics residues from honey samples

Li, Duo, Li, Tengfei, Wang, Lei, Ji, Shunli
Journal of chromatography 2018 v.1581-1582 pp. 1-7
Fourier transform infrared spectroscopy, adsorbents, binding capacity, chromatography, coatings, detection limit, dihydrostreptomycin, honey, iron oxides, kanamycin, magnetism, nanoparticles, nitrogen, pH, polyvinyl alcohol, solid phase extraction, surface area, thermogravimetry, transmission electron microscopes, transmission electron microscopy
The authors describe magnetic nanoparticles comprising of a Fe3O4 core and a polyvinyl alcohol (PVA) coating for use in dispersive solid phase extraction (DSPE) of aminoglycoside antibiotics (AAs). The sorbent was investigated by Transmission electron microscope (TEM), Fourier transform infrared spectrometer (FT-IR), thermo-gravimetric analysis (TGA), nitrogen adsorption-desorption isotherms and so on. The extraction conditions consisting of the proportion of ACN, pH value, buffer concentration and sorbent dosage were optimized. The nanoparticles have a large surface area (73.28 m2 g−1), a high binding capacity (11.33 μmol g−1) and a fast binding time (30 s). The Fe3O4@PVA is shown to be an effective adsorbent for the enrichment of AAs (streptomycin, dihydrostreptomycin and kanamycin) in spiked honey. The limits of detection are as low as 0.993, 0.913 and 1.23 μg kg−1 for streptomycin, dihydrostreptomycin and kanamycin, respectively. The recoveries varied from 82.9% to 100.7% at the three spiking levels tested (40, 400, 4000 μg⋅kg−1). Intra-day and inter-day assay precision were < 12.1% (n = 6) and <12.8% (n = 3) at three spiking levels. These data showed that the method could be applied to the extraction of AAs in honey samples.