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A sensitive and accurate vortex-assisted liquid-liquid microextraction-gas chromatography-mass spectrometry method for urinary triazoles

Author:
Machado, Simone Caetani, Souza, Bruna Maciel, de Aguiar Marciano, Luiz Paulo, Souza Pereira, Ana Flávia, de Carvalho, Diailison Teixeira, Martins, Isarita
Source:
Journal of chromatography 2019 v.1586 pp. 9-17
ISSN:
0021-9673
Subject:
cyproconazole, environmental monitoring, gas chromatography-mass spectrometry, propiconazole, quality control, tebuconazole, triadimefon, triadimenol, triazole fungicides, urine
Abstract:
The development and validation of an innovative, simple, rapid, selective and sensitive vortex-assisted liquid-liquid microextraction-gas chromatography- mass spectrometry (VALLME-GC/MS) method to seven triazole fungicides in urine is reported. The confidence parameters were exhaustive evaluated and linearity (r > 0.99), precision (below 15%, to quality controls, and 20%, to lower limit of quantification), accuracy and robustness were adequate for the analysis of cyproconazole, epoxiconazole, metconazole, tebuconazole, triadimenol, propiconazole and triadimefon. To assess the applicability of the method, analyses were performed in volunteers exposed to triazoles in the last 30 days. The method demonstrated satisfactory analytical performance, with sufficient detectability to be applied as a potential tool to biomonitoring individuals exposed to the seven evaluated fungicides.
Agid:
6250723