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Cycloartane-type triterpenoid derivatives and a flavonoid glycoside from the burs of Castanea crenata

Author:
Kim, Nanyoung, Park, SeonJu, Nhiem, Nguyen Xuan, Song, Jae-Hyoung, Ko, Hyun-Jeong, Kim, Seung Hyun
Source:
Phytochemistry 2019 v.158 pp. 135-141
ISSN:
0031-9422
Subject:
Castanea crenata, antiviral properties, glycosides, kaempferol, nuclear magnetic resonance spectroscopy, spectral analysis, triterpenoids
Abstract:
Five undescribed cycloartane-type triterpenoids, which were isolated for the first time from the genus, and a flavonoid glycoside together with 11 known compounds were isolated from the burs of Castanea crenata. The structures were elucidated based on the spectroscopic analysis of 1D and 2D NMR and MS data. All isolated compounds were evaluated for antiviral activities against HRV1B-, CVB3-, and PR8-infected cells. Most kaempferol derivatives showed statistically significant antiviral activities against HRV1B-infected cells. Among the tested compounds, kaempferol-3-O-[2″,6″-di-O-Z-p-coumaroyl]-β-d-glucopyranoside exhibited the most consistent and effective antiviral activities against all infections.
Agid:
6250985