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Triterpenoids from the twigs and leaves of Rhododendron latoucheae by HPLC‒MS‒SPE‒NMR
- Liu, Fei, Wang, Ya-Nan, Li, Yong, Ma, Shuang-Gang, Qu, Jing, Liu, Yun-Bao, Niu, Chang-Shan, Tang, Zhong-Hai, Li, Yu-Huan, Li, Li, Yu, Shi-Shan
- Tetrahedron 2019 v.75 no.2 pp. 296-307
- Rhododendron, branches, chemical reactions, chemical structure, circular dichroism spectroscopy, inhibitory concentration 50, leaves, nuclear magnetic resonance spectroscopy, quinones, triterpenoids
- Twenty-one new triterpenoids (1–21) and fifteen known triterpenoids (22–36) were rapidly isolated from Rhododendron latoucheae by the hyphenated technique HPLC‒MS‒SPE‒NMR. The structures of 1−21 were elucidated from NMR, MS, and extensive spectroscopic methods and electronic circular dichroism (ECD) analyses. Notably, compound 1 is the first example of 23-norquinone methide. Compounds 1, 2, 6, 14, 21, 28, 30, and 35 exhibited potent activities against HSV-1, with IC50 values from 0.71 to 14.62 μM.