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Synthesis of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones via microwave-assisted base-free intramolecular cross dehydrogenative coupling

Author:
Gu, Chang-Xue, Chen, Wen-Wen, Xu, Bin, Xu, Ming-Hua
Source:
Tetrahedron 2019 v.75 no.12 pp. 1605-1611
ISSN:
0040-4020
Subject:
catalytic activity, chemical structure, coumarins, dehydrogenation, microwave treatment, palladium, quinolones
Abstract:
A microwave-assisted base-free intramolecular cross dehydrogenative coupling (CDC) of 3-aniline substituted coumarins and quinolinones have been developed. A broad range of indolo[2,3-c]coumarins and indolo[2,3-c]quinolinones can be easily afforded in good to high yields (up to 93%) under palladium catalysis. The method is among the most straightforward and convenient ways to access these fused polyheterocycles.
Agid:
6251151