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Ru-catalyzed synthesis of substituted phthalides through C–H bond activation and functionalization

Author:
Kianmehr, Ebrahim, Fardpour, Maryam, Darvish, Ali, Kharat, Ali Nemati, Weng Ng, Seik
Source:
Tetrahedron letters 2019 v.60 no.10 pp. 699-702
ISSN:
0040-4039
Subject:
acrylates, anhydrides, carbon-hydrogen bond activation, chemical bonding, chemical structure, decarboxylation, phthalides
Abstract:
Synthesis of substituted phthalides through a ruthenium-catalyzed reaction of phthalic anhydrides with acrylates is described. The reaction proceeds via CH bond activation and leads to the formation of vinylated phthalides through a successive double vinylation accompanied by decarboxylation and annulation reactions.
Agid:
6251201