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Ru-catalyzed synthesis of substituted phthalides through C–H bond activation and functionalization
- Kianmehr, Ebrahim, Fardpour, Maryam, Darvish, Ali, Kharat, Ali Nemati, Weng Ng, Seik
- Tetrahedron letters 2019 v.60 no.10 pp. 699-702
- acrylates, anhydrides, carbon-hydrogen bond activation, chemical bonding, chemical structure, decarboxylation, phthalides
- Synthesis of substituted phthalides through a ruthenium-catalyzed reaction of phthalic anhydrides with acrylates is described. The reaction proceeds via CH bond activation and leads to the formation of vinylated phthalides through a successive double vinylation accompanied by decarboxylation and annulation reactions.