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Optical resolution via catalytic generation of chiral auxiliary

Author:
Kiyama, Hiroki, Inokuma, Tsubasa, Kuroda, Yusuke, Yamaoka, Yousuke, Takasu, Kiyosei, Yamada, Ken-ichi
Source:
Tetrahedron letters 2019 v.60 no.2 pp. 175-177
ISSN:
0040-4039
Subject:
alcohols, enantiomers, gel chromatography, hydrolysis, imines
Abstract:
A new catalytic method for separating enantiomers of racemic compounds is proposed. Catalytic asymmetric addition of racemic trans-2-substituted cyclohexanols to imines provided diastereomeric mixtures of aminals, and the subsequent separation of the enantiomers by silica-gel column chromatography and the hydrolysis of the aminals produced the alcohols in an optically active form.
Agid:
6251202