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Vaginal co-colonization with multiple Group B Streptococcus serotypes
- Khatami, Ameneh, Randis, Tara M., Tavares, Larissa, Gegick, Margaret, Suzman, Evan, Ratner, Adam J.
- Vaccine 2019 v.37 no.3 pp. 409-411
- Streptococcus agalactiae, epidemiology, monitoring, pathogens, quantitative polymerase chain reaction, serotypes, vaccination, vaccines, women, United States
- Group B Streptococcus (GBS) is a neonatal pathogen frequently transmitted from maternal asymptomatic vagino-rectal colonization. Co-colonization with multiple GBS serotypes, which has implications for type-specific vaccination strategies, is difficult to detect with standard microbiologic techniques. We designed a nested real-time PCR assay to detect vaginal co-colonization in samples from a cohort of non-pregnant women (N = 433). 6/91 (6.6%) GBS-positive samples harbored ≥2 GBS serotypes, with over-representation of serotype V among co-colonized samples. Serotype IV GBS was more prevalent (>10%) in this cohort than in previously reported United States studies. Ongoing surveillance of GBS serotype epidemiology and co-colonization is indicated.