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Systems pharmacology uncovers the mechanisms of anti-asthma herbal medicine intervention (ASHMI) for the prevention of asthma

Zhou, Wei, Chen, Ziyi, Li, Weiqing, Wang, Yonghua, Li, Xiumin, Yu, Haiqiong, Ran, Peixin, Liu, Zhigang
Journal of functional foods 2019 v.52 pp. 611-619
Oriental traditional medicine, asthma, functional foods, health care costs, herbal medicines, morbidity, mortality, pharmacology, therapeutics
Asthma is a common chronic inflammatory airway disorder associated with considerable morbidity, mortality and increased health care costs worldwide. Traditional Chinese medicine (TCM) as a functional food characterized by multi-compound and multi-target have been proven to be effective in treating asthma based on a holistic way. However, the potential molecular or systems mechanism of TCM to anti-asthma has not yet been fully elucidated. A systems pharmacology-based method combining the ADME evaluation, herb feature mapping, drug target fishing, network pharmacology, as well as pathway analysis is developed to comprehensively elucidate the potential therapeutic mechanism of asthma, exemplified by the anti-asthma herbal medicine intervention (ASHMI). Our study not only provides a comprehensive thinking for better understanding the complex action mechanism of ASHMI on asthma from a system level, but also proposed a rational novel way to facilitate the treatment of asthma.