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Chemical constituents from the twigs and leaves of Trichilia sinensis and their biological activities

Author:
Cao, Dong-Hua, Sun, Peng, Liao, Shang-Gao, Gan, Li-She, Yang, Lin, Yao, Jian-Neng, Zhang, Zong-Yi, Li, Jin-Feng, Zheng, Xiao-Ling, Xiao, Yi-Dian, Xiao, Chun-Fen, Zhang, Ping, Hu, Hua-Bin, Xu, You-Kai
Source:
Phytochemistry letters 2019 v.29 pp. 142-147
ISSN:
1874-3900
Subject:
Escherichia coli, Heynea velutina, anti-inflammatory activity, antibacterial properties, bacteria, branches, chemical composition, chemical constituents of plants, leaves, limonoids, nitric oxide, nuclear magnetic resonance spectroscopy, phenolic acids, spectral analysis
Abstract:
Phytochemical investigation on the twigs and leaves of Trichilia sinensis led to the isolation of two previously undescribed limonoids (i.e., trichiliasinenoids D and E, 1 and 2), two previously undescribed phenolic acids (3 and 4), and one previously undescribed natural phenolic acid dimer (5), together with 11 known compounds (6-16). Their structures were elucidated by extensive spectroscopic analysis (IR, UV, HRESIMS, 1D and 2D NMR) and chemical techniques. The potential anti-inflammatory activities of all the compounds were evaluated in lipopolysaccharide-stimulated RAW 264.7 cells. Among these isolates, compounds 1, 2, 6, and 11-13 expressed weak NO inhibition. The antibacterial activities of all the compounds against bacteria were also tested in vitro. Compound 16 exhibited moderate antibacterial activities against Escherichia Coli.
Agid:
6252769