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Bioassay-guided isolation of lanostane-type triterpenoids as α-glucosidase inhibitors from Ganoderma hainanense

Author:
Ma, Lie-Feng, Yan, Jia-Jie, Lang, Huang-Yan, Jin, Li-Chao, Qiu, Fei-Jun, Wang, Yue-Jun, Xi, Zhi-Fang, Shan, Wei-Guang, Zhan, Zha-Jun, Ying, You-Min
Source:
Phytochemistry letters 2019 v.29 pp. 154-159
ISSN:
1874-3900
Subject:
Ganoderma, acarbose, alpha-glucosidase, chemical constituents of plants, dietary supplements, enzyme inhibition, enzyme inhibitors, fruiting bodies, functional foods, glycemic control, glycemic effect, mushrooms, structure-activity relationships, triterpenoids, China
Abstract:
Ganoderma hainanense, an edible mushroom mainly distributed in Southern China, has long been used as a functional food with considerable health benefits. Bioassay-guided phytochemical research on the fruiting bodies of G. hainanense led to the isolation of 22 lanostane-type triterpenoids, including two new compounds 3-acetyl-ganodermadiol (1) and 3-acetyl-lucidumol B (2). In an in-vitro assay, sixteen out of the twenty-two triterpenoids were found to possess more potent α-glucosidase inhibitory activity than the positive control acarbose. Preliminary structure-activity relationship (SAR) analysis indicated that the side chain structures of these compounds could significantly influence the activity. Results of the present study revealed that lanostane-type triterpenoids with α-glucosidase inhibitory activity may contribute to the hypoglycaemic effects of G. hainanense in the folk usage, and also the potentiality to develop G. hainanense as dietary supplement for glycemic control.
Agid:
6252773