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Bioassay-guided isolation of lanostane-type triterpenoids as α-glucosidase inhibitors from Ganoderma hainanense

Ma, Lie-Feng, Yan, Jia-Jie, Lang, Huang-Yan, Jin, Li-Chao, Qiu, Fei-Jun, Wang, Yue-Jun, Xi, Zhi-Fang, Shan, Wei-Guang, Zhan, Zha-Jun, Ying, You-Min
Phytochemistry letters 2019 v.29 pp. 154-159
Ganoderma, acarbose, alpha-glucosidase, chemical constituents of plants, dietary supplements, enzyme inhibition, enzyme inhibitors, fruiting bodies, functional foods, glycemic control, glycemic effect, mushrooms, structure-activity relationships, triterpenoids, China
Ganoderma hainanense, an edible mushroom mainly distributed in Southern China, has long been used as a functional food with considerable health benefits. Bioassay-guided phytochemical research on the fruiting bodies of G. hainanense led to the isolation of 22 lanostane-type triterpenoids, including two new compounds 3-acetyl-ganodermadiol (1) and 3-acetyl-lucidumol B (2). In an in-vitro assay, sixteen out of the twenty-two triterpenoids were found to possess more potent α-glucosidase inhibitory activity than the positive control acarbose. Preliminary structure-activity relationship (SAR) analysis indicated that the side chain structures of these compounds could significantly influence the activity. Results of the present study revealed that lanostane-type triterpenoids with α-glucosidase inhibitory activity may contribute to the hypoglycaemic effects of G. hainanense in the folk usage, and also the potentiality to develop G. hainanense as dietary supplement for glycemic control.