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A new constituent against rheumatoid arthritis from the flower buds of Lonicera japonica

Author:
Xiao, Yu, Li, Bing, Liu, Jun
Source:
Phytochemistry letters 2019 v.29 pp. 160-164
ISSN:
1874-3900
Subject:
Lonicera japonica, anti-inflammatory activity, flower buds, inflammation, mice, rheumatoid arthritis, spectroscopy, therapeutics, tissues
Abstract:
In this study, two new compounds named as 8,4′-di-O-methylquercetin-3′-O-β-galactosyl-3-O-β-glucopyranoside (1) and 6-formyl-5-hydroxyl-4-ethyl-2-hydroxymethyl-1H-indene (2), were isolated from the flower buds of Lonicera japonica. Structures of compound 1 and 2 were determined by spectroscopic methods. Additionally, compound 1 showed therapeutic effects against rheumatoid arthritis (RA) in collagen-induced arthritis (CIA) mice through significantly reducing the inflammatory responses in the joint tissues. These results suggested that compound 1 exerted potent chondroprotective and anti-inflammatory effects against RA.
Agid:
6252778