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Cytotoxic butenolides and diphenyl ethers from the endophytic fungus Pestalotiopsis sp.

Author:
Yang, Beiye, Tong, Qingyi, Lin, Shuang, Guo, Jieru, Zhang, Jinwen, Liu, Junjun, Wang, Jianping, Zhu, Hucheng, Hu, Zhengxi, Zhang, Yonghui
Source:
Phytochemistry letters 2019 v.29 pp. 186-189
ISSN:
1874-3900
Subject:
Pestalotiopsis, carbon, cell lines, cytotoxicity, diphenyl ethers, endophytes, fungi, humans, inhibitory concentration 50, neoplasms, spectral analysis
Abstract:
Chemical investigation of the plant endophytic fungus Pestalotiopsis sp. afforded two new butenolides, pestalolides B and C (1 and 2), two new diphenyl ethers, pestalotethers E and F (3 and 4), together with seven known compounds (5–11). Their structures were established by extensive spectroscopic analyses and the absolute configuration of 1 was further confirmed by ECD calculation. Structurally, compound 1 represents the first example of a new type of butenolide derivatives, bearing an unprecedented carbon scaffold having 13 carbon atoms. Compounds 1–4 were evaluated for the cytotoxic activities, and compound 1 showed remarkable inhibitory potency against human tumor HL60, U87MG, MDA-MB-231, and HEP-3B cell lines, with IC50 values of 1.42, 5.90, 5.90, and 4.29 μM, respectively.
Agid:
6252781