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The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study

Terburg, David, Scheggia, Diego, Triana del Rio, Rodrigo, Klumpers, Floris, Ciobanu, Alexandru Cristian, Morgan, Barak, Montoya, Estrella R., Bos, Peter A., Giobellina, Gion, van den Burg, Erwin H., de Gelder, Beatrice, Stein, Dan J., Stoop, Ron, van Honk, Jack
Cell 2018 v.175 no.3 pp. 723-735.e16
amygdala, brain stem, defensive behavior, escape behavior, freezing, humans, rats
Rodent research delineates how the basolateral amygdala (BLA) and central amygdala (CeA) control defensive behaviors, but translation of these findings to humans is needed. Here, we compare humans with natural-selective bilateral BLA lesions to rats with a chemogenetically silenced BLA. We find, across species, an essential role for the BLA in the selection of active escape over passive freezing during exposure to imminent yet escapable threat (Timm). In response to Timm, BLA-damaged humans showed increased startle potentiation and BLA-silenced rats demonstrated increased startle potentiation, freezing, and reduced escape behavior as compared to controls. Neuroimaging in humans suggested that the BLA reduces passive defensive responses by inhibiting the brainstem via the CeA. Indeed, Timm conditioning potentiated BLA projections onto an inhibitory CeA pathway, and pharmacological activation of this pathway rescued deficient Timm responses in BLA-silenced rats. Our data reveal how the BLA, via the CeA, adaptively regulates escape behavior from imminent threat and that this mechanism is evolutionary conserved across rodents and humans.