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Flipping ATP to AMPlify Kinase Functions

Author:
Sheetz, Joshua B., Lemmon, Mark A.
Source:
Cell 2018 v.175 no.3 pp. 641-642
ISSN:
0092-8674
Subject:
adenosine monophosphate, adenosine triphosphate, enzyme activity, phosphates, protein kinases
Abstract:
Understanding protein kinase family members that lack key catalytic residues—or pseudokinases—is a major challenge in cell signaling. In this issue of Cell, Sreelatha et al. (2018) describe how one pseudokinase transfers adenosine monophosphate (AMP) rather than phosphate to protein substrates, revealing unexpected catalytic diversity for the kinase fold.
Agid:
6253829