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Flexible heteroionic calcium-magnesium alginate beads for controlled drug release
- Sanchez-Ballester, Noelia M., Soulairol, Ian, Bataille, Bernard, Sharkawi, Tahmer
- Carbohydrate polymers 2019 v.207 pp. 224-229
- alginates, drug delivery systems, gelation, ibuprofen, magnesium, pH
- In the present work heteroionic calcium-magnesium alginate beads have been prepared by ionotropic gelation using different Ca:Mg ratios. This simple and straightforward approach allowed the obtention of CaMg-alginate beads presenting different mechanical performance depending on the Mg:Ca ratio. The dynamic swelling behavior of the beads was investigated. Increase in the quantity of Mg2+ incorporated in the beads increased the rate of swelling at pH 1.2 and pH 7.2. Finally, the release of ibuprofen was investigated. It was found that increasing the Mg2+ present in the beads raised the drug release rate.