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Construction of blood compatible chitin/graphene oxide composite aerogel beads for the adsorption of bilirubin

Song, Xi, Huang, Xiuhong, Li, Zhixiong, Li, Zhentao, Wu, Keke, Jiao, Yanpeng, Zhou, Changren
Carbohydrate polymers 2019 v.207 pp. 704-712
Fourier transform infrared spectroscopy, X-ray diffraction, adsorbents, adsorption, aerogels, anticoagulant activity, aqueous solutions, bilirubin, blood, carbon dioxide, chitin, compression strength, graphene oxide, hemolysis, scanning electron microscopy, sodium hydroxide, strength (mechanics), surface area, thermal stability, urea
Excess bilirubin in blood can provoke hepatic damage and related malfunctions. Hereby we designed and constructed a novel bilirubin adsorbent, called chitin/graphene oxide (Ch/GO) composite aerogel beads, for efficient, fast and safe removal for bilirubin. The Ch/GO aerogel beads were prepared from chitin and GO in a NaOH/urea aqueous solution, followed dried by supercritical carbon dioxide. The morphology, structure and properties of the Ch/GO composite aerogel beads were characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET), fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and compressive strength measurement. The results indicated that GO was successfully bound to chitin matrix with enhanced surface area, thermal stability and mechanical strength. The adsorption capacity of Ch/GO composite aerogel beads for bilirubin was examined by UV–vis spectrophotometry. Moreover, batch adsorption results revealed that the Ch/GO composite aerogel beads showed excellent bilirubin adsorption capacity (484.1 ± 16.9 mg/g) and short adsorption equilibrium time (0.5 h) under optimized condition. Furthermore, the Ch/GO aerogel beads exhibited a lower hemolysis property and improved anticoagulant property. Hence, this work provided a new strategy to develop a novel blood compatible bilirubin adsorbent, which presented good application potential for bilirubin adsorption.