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Microwave- assisted green synthesis of acrylamide cyclodextrin-grafted silylated bentonite for the controlled delivery of tetracycline hydrochloride

Author:
Mullassery, Manohar D., Fernandez, Noeline B., R, Surya, Thomas, Diana
Source:
Sustainable chemistry and pharmacy 2018 v.10 pp. 103-111
ISSN:
2352-5541
Subject:
Fourier transform infrared spectroscopy, X-ray diffraction, acrylamides, bentonite, beta-cyclodextrin, biocompatibility, colon, drug delivery systems, drugs, green chemistry, pH, scanning electron microscopy, stomach, tetracycline, thermal analysis
Abstract:
In this work a novel composite, acrylamide β-cyclodextrin grafted silylated bentonite was synthesized for the controlled delivery of tetracycline hydrochloride (TCH). Characterization of the drug delivery system was carried out using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), thermal analysis etc. The equilibrium swelling behaviour of the composite was studied and the result showed a maximum at pH 7.4. The in vitro drug release study of tetracycline hydrochloride at pH 7.4 was shown to be divided into three stages, first of which was the initial burst followed by slower release and finally a constant rate of release. In vitro biocompatibility study was performed and the result showed good biocompatibility of the composite in the concentration range of 50–450 μg/mL. Drug delivery study of the composite proved that TCH could be successfully released in a controlled manner in the colon without much loss of drug in the stomach.
Agid:
6254595