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Antibiotic susceptibility profiles of Mycoplasma hyorhinis strains isolated from swine in Hungary

Author:
Bekő, Katinka, Felde, Orsolya, Sulyok, Kinga M., Kreizinger, Zsuzsa, Hrivnák, Veronika, Kiss, Krisztián, Biksi, Imre, Jerzsele, Ákos, Gyuranecz, Miklós
Source:
Veterinary microbiology 2019 v.228 pp. 196-201
ISSN:
0378-1135
Subject:
Mycoplasma hyorhinis, active ingredients, antibiotic resistance, arthritis, doxycycline, financial economics, florfenicol, fluoroquinolones, gamithromycin, gentamicin, lincomycin, minimum inhibitory concentration, oxytetracycline, pathogens, pneumonia, spectinomycin, swine, tiamulin, tylosin, Hungary
Abstract:
Mycoplasma hyorhinis is a common pathogen of swine causing mainly polyserositis and arthritis, but it has also been implicated as a cause of pneumonia. The economic losses due to M. hyorhinis infection could be reduced by antibiotic treatment. The aim of this study was to determine minimal inhibitory concentrations (MIC) of antibiotics potentially used to combat M. hyorhinis in swine production.Thirty-eight Hungarian M. hyorhinis strains isolated between 2014 and 2017 were examined by microbroth dilution tests for fifteen antimicrobial agents. Low MIC values of tetracyclines (MIC50 0.078 μg/ml for doxycycline, ≤0.25 μg/ml for oxytetracycline) and pleuromutilins (MIC50 0.156 μg/ml for tiamulin, ≤0.039 μg/ml for valnemulin) were detected against all strains. Fluoroquinolones (MIC50 0.625 μg/ml), gentamicin (MIC50 1 μg/ml) and florfenicol (MIC50 2 μg/ml) inhibited the growth of Hungarian isolates at moderate MIC values. Most of the strains were inhibited by spectinomycin with low or moderate MIC values (MIC50 4 μg/ml) except one strain (>64 μg/ml). Numerous isolates showed decreased susceptibility to macrolides and lincomycin (MIC90 >64 for tylosin, tilmicosin, tulathromycin, gamithromycin, lincomycin, 8 μg/ml for tylvalosin).This study serves as evidence for the increasing resistance to macrolides and lincomycin in mycoplasmas, and also reports the occurrence of strains with extremely high MIC values to spectinomycin thus emphasizes the importance of the prudent use of antibiotics. Based on our results, tetracyclines and pleuromutilins are the most active compounds in vitro against the Hungarian M. hyorhinis strains.
Agid:
6255478