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Self-assembled CpG oligodeoxynucleotides conjugated hollow gold nanospheres to enhance cancer-associated immunostimulation

Author:
Luo, Jing, Cheng, Yang, He, Xiao-Yan, Liu, Yi, Peng, Na, Gong, Zhi-Wei, Wu, Kui, Zou, Tao
Source:
Colloids and surfaces 2019 v.175 pp. 248-255
ISSN:
0927-7765
Subject:
colloids, cytokines, cytotoxicity, gold, immunotherapy, nanogold, nanospheres, oligodeoxyribonucleotides, photothermotherapy, secretion
Abstract:
To realize efficiently cellular uptake and enhance the immunostimulation, thiolated cytosine-phosphate-guanine (CpG) oligodeoxynucleotides (ODNs) were self-assembled on hollow gold nanospheres (HGNs) to form CpG-HGNs. The cellular uptake of CpG-HGNs in immune cells was studied in RAW 264.7 cells. Due to the enhanced delivery efficiency, CpG-HGNs exhibited a higher immune stimulatory activity compared with CpG ODNs, resulting in a dramatically enhanced secretion of proinflammatory cytokines. In addition, CpG-HGNs showed low cytotoxicity in RAW 264.7 cells. CpG-HGNs could potentially realize synergistic photothermal therapy and immunotherapy in vivo.
Agid:
6255942