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Facile fabrication of water-dispersible nanocomposites based on hexa-peri-hexabenzocoronene and Fe₃O₄ for dual mode imaging (fluorescent/MR) and drug delivery

Song, Meng-Meng, Xiang, Hui-Hui, Fei, Meng-Yu, Lu, Da-Peng, Jiang, Tong-Cui, Yu, Yong-Qiang, Liu, Rui, Shen, Yu-Xian
RSC advances 2018 v.8 no.71 pp. 40554-40563
composite polymers, cytotoxicity, doxorubicin, drug carriers, fluorescence, hepatoma, humans, image analysis, iron oxides, light scattering, nanocomposites, nanoparticles
The facile fabrication of multifunctional nanocomposites (Fe₃O₄/HBC@F127) consisting of superparamagnetic Fe₃O₄ nanoparticles and fluorescent organic hexa-peri-hexabenzocoronene (HBC) molecules incorporated in block copolymer diacylphospholipid–polyethyleneglycol F127 have been demonstrated for dual mode imaging (fluorescent/MR) and drug delivery. The obtained nanocomposites were water-dispersible, stable and biocompatible, as confirmed by dynamic light scattering (DLS) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Relativity measurements showed a T₂ relaxivity (r₂) of 214.61 mM⁻¹ s⁻¹, which may be used as T₂-weighted MR imaging agents. In vitro imaging studies indicated that the nanocomposites had good MR and fluorescence imaging effects with low cytotoxicity. Besides, the developed nanocomposites could also be applied as drug delivery vehicles. Doxorubicin (DOX) loaded Fe₃O₄/HBC@F127 nanocomposites significantly inhibited the growth of human hepatoma cells (HepG2). These findings suggested that the facile synthesized multifunctional nanocomposites may be used as a platform for dual mode imaging (both MR and fluorescence) and drug delivery.