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Cholinesterase inhibitory isoquinoline alkaloids from Corydalis mucronifera

Author:
Zhang, Jun, Zhang, Chen, Xu, Fu-Chun, Quesheng,, Zhang, Qing-Ying, Tu, Peng-Fei, Liang, Hong
Source:
Phytochemistry 2019 v.159 pp. 199-207
ISSN:
0031-9422
Subject:
Corydalis, X-ray diffraction, acetylcholinesterase, cholinesterase, circular dichroism spectroscopy, enzyme inhibition, inhibitory concentration 50, isoquinoline alkaloids, mass spectrometry, nuclear magnetic resonance spectroscopy
Abstract:
Eight previously undescribed isoquinoline alkaloids, mucroniferanines H-M, together with 16 known isoquinoline alkaloids, were isolated from Corydalis mucronifera Maxim.. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic and HRMS data, and their absolute configurations were established by computational electronic circular dichroism (ECD) calculations and X-ray diffraction data. Mucroniferanine L is reported as the first natural amide bond linked isoquinoline alkaloid dimer. The isolated compounds were evaluated for AChE and BuChE inhibitory activities and mucroniferanine H showed significant activities with IC50 values of 2.31 μM and 36.71 μM, respectively.
Agid:
6257651