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CGRP Antibodies as Prophylaxis in Migraine

Author:
Edvinsson, Lars
Source:
Cell 2018 v.175 no.7 pp. 1719
ISSN:
0092-8674
Subject:
calcitonin gene-related peptide, disease control, drugs, ligands, markets, migraine, monoclonal antibodies, pain
Abstract:
Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. To view this Bench to Bedside, open or download the PDF.
Agid:
6258028