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Enhancement of thermal imaging by iron oxide nanoparticle – Preliminary study

Angeline Kirubha, S.P., Rajput, Alankruti
Biocatalysis and agricultural biotechnology 2019 v.17 pp. 352-360
Fourier transform infrared spectroscopy, chemical bonding, coprecipitation, drugs, ferric chloride, ferrous chloride, immunoassays, iron, magnetic fields, magnetic resonance imaging, nanoparticles, neoplasms, polyethylene glycol, scanning electron microscopy, surfactants, temperature, thermography, tissues
Magnetic nanoparticles (MNP) have been developed in the recent years for various applications like cell separation, immunoassay, and drug delivery. The present study involves the synthesis of stable, biocompatible Iron oxide MNP by coprecipitation of ferric chloride and ferrous chloride with Polyethylene glycol (PEG) as a surfactant to coat the nanoparticles twice. Scanning electron microscopic (SEM) images confirm the formation of uniform MNPs of size 12–17 nm. The peak at 582.2 cm−1 in the Fourier transform infrared spectrum (FTIR) corresponds to the Fe–O bond and the peak at 1104.1 cm−1 corresponds to a characteristic peak of PEG binding to the iron core. Tumor tissues selectively targeted with MNPs when placed in a magnetic field increases the temperature of the tumor tissues. The phantom study shows that there is a minimum of 1.3 °C and a maximum of 6.7 °C rise in temperature with increasing concentration of the nanoparticles embedded in the phantoms; this proved the possibility of enhancement of thermal images using MNPs and its usage for thermal ablation of cancer. MNPs can also be used as a contrast agent for magnetic resonance imaging (MRI).