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Pharmacological and toxicological health risk of food (herbal) supplements adulterated with erectile dysfunction medications

Author:
Žuntar, Irena, Krivohlavek, Adela, Kosić-Vukšić, Josipa, Granato, Daniel, Bursać Kovačević, Danijela, Putnik, Predrag
Source:
Current opinion in food science 2018 v.24 pp. 9-15
ISSN:
2214-7993
Subject:
adulterated products, dietary supplements, drugs, enzymes, food science, men, patients, public health, risk
Abstract:
Erectile dysfunction is one of the most common sexual disorders among men, with large number of patients worldwide. This is a multifactorial disease with (non)organic causes while main oral drugs for the treatment are phosphodiesterase type 5 inhibitors (PDE5Is). Currently, sildenafil, vardenafil, tadalafil, udenafil, mirodenafil, lodenafil and avanafil are used. Worldwide use of herbal and dietary supplements for alleviating this problem is on a rise, as many consumers perceive these products as ‘healthier’ and safer as compared to conventional pharmaceutical preparations. However, adulteration of food supplements with PDE5Is and/or its analogues is very common and represents serious public health concern. This review address the issues with pharmacological and toxicological health risks of food supplements adulterated with erectile dysfunction medications.
Agid:
6258958