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Current state of the polymeric delivery systems of fluoroquinolones – A review

Author:
Mulas, Karolina, Stefanowicz, Zdzisława, Oledzka, Ewa, Sobczak, Marcin
Source:
Journal of controlled release 2019 v.294 pp. 195-215
ISSN:
0168-3659
Subject:
antibiotics, chemical bonding, drug carriers, drug therapy, drug toxicity, drugs, fluoroquinolones, polymers
Abstract:
Recently, growing interest in polymers (natural and synthetic) as drug carriers in controlled release formulations and drug targeting systems that may improve the efficacy of treatment and reduce the side effects of a drug therapy, has been observed. Special attention has been paid to improving the effectiveness of antibiotics, which constitute a very important, often life-saving group of drugs. In this paper, we review polymers as macromolecular carriers of fluoroquinolones, a group of antibiotics with a broad spectrum of activity. We consider both physical intermixtures and chemical conjugates, although we discuss in greater depth the latter type of coupling, in which covalent bonds between drug molecules and polymers occur.
Agid:
6259317