U.S. flag

An official website of the United States government

PubAg

Main content area

Dietary Curcuma longa enhances resistance against Eimeria maxima and Eimeria tenella infections in chickens

Author:
Kim, Duk Kyung, Lillehoj, Hyun S., Lee, Sung Hyen, Jang, Seung I., Lillehoj, Erik P., Bravo, David
Source:
Poultry science 2013 v.92 no.10 pp. 2635
ISSN:
0032-5791
Subject:
Curcuma longa, Eimeria maxima, Eimeria tenella, anti-inflammatory activity, antibodies, blood serum, broiler chickens, cell proliferation, cell-mediated immunity, coccidiosis, concanavalin A, dietary supplements, digestive system, feces, gene expression regulation, genes, humoral immunity, immune response, lymphocytes, mammals, microarray technology, oocysts, poultry production, spleen, transcriptome
Abstract:
The effects of dietary supplementation with an organic extract of Curcuma longa on systemic and local immune responses to experimental Eimeria maxima and Eimeria tenella infections were evaluated in commercial broiler chickens. Dietary supplementation with C. longa enhanced coccidiosis resistance as demonstrated by increased BW gains, reduced fecal oocyst shedding, and decreased gut lesions compared with infected birds fed a nonsupplemented control diet. The chickens fed C. longa -supplemented diet showed enhanced systemic humoral immunity, as assessed by greater levels of serum antibodies to an Eimeria microneme protein, MIC2, and enhanced cellular immunity, as measured by concanavalin A-induced spleen cell proliferation, compared with controls. At the intestinal level, genome-wide gene expression profiling by microarray hybridization identified 601 differentially expressed transcripts (287 upregulated, 314 downregulated) in gut lymphocytes of C. longa -fed chickens compared with nonsupplemented controls. Based on the known functions of the corresponding mammalian genes, the C. longa -induced intestinal transcriptome was mostly associated with genes mediating anti-inflammatory effects. Taken together, these results suggest that dietary C. longa could be used to attenuate Eimeria -induced, inflammation-mediated gut damage in commercial poultry production.
Agid:
62602
Handle:
10113/62602