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New cycloartanes and new iridoids from Dolichandrone spathacea collected in the mangrove forest of Soc Trang province, Vietnam

Nguyen, Van Tuan, Do, Le Quyen, Nguyen, The Anh, Nguyen, Tuan Thanh, Tran, Van Loc, Ho, Ngoc Anh, Tran, Van Chien, Tran, Van Sung, Tran, Thi Phuong Thao
Journal of Asian natural products research 2018 v.20 no.9 pp. 889-896
cytotoxicity, human cell lines, humans, inhibitory concentration 50, iridoids, leaves, mangrove forests, neoplasm cells, nuclear magnetic resonance spectroscopy, spectral analysis, Vietnam
Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5–8), were isolated from the leaves and barks of Dolichandrone spathacea. Their structures were elucidated by means of extensive analysis of their HRESIMS, 1D and 2D NMR spectroscopic data. All of these compounds have been isolated for the first time from this plant. Compounds 1, 2, 5, and 7 were evaluated for their cytotoxic activity in vitro against four human cancer cell lines KB, Lu, HepG2, and MCF7. The results showed that only compound 2 exhibited a good cytotoxicity against KB cell line with IC₅₀ of 18.77 μM.