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Effect of PLGA block molecular weight on gelling temperature of PLGA‐PEG‐PLGA thermoresponsive copolymers

Author:
Steinman, Noam Y., Haim‐Zada, Moran, Goldstein, Isaac A., Goldberg, Ayelet H., Haber, Tom, Berlin, Jacob M., Domb, Abraham J.
Source:
Journal of polymer science 2019 v.57 no.1 pp. 35-39
ISSN:
0887-624X
Subject:
acetaminophen, aqueous solutions, biodegradability, composite polymers, gelatinization temperature, hydrogels, medicinal properties, molecular weight
Abstract:
Thermoresponsive, biodegradable polymeric hydrogel networks are used widely in medicinal applications. Poly(d,l‐lactic acid‐co‐glycolic acid)‐b‐poly(ethylene glycol)‐b‐poly(d,l‐lactic acid‐co‐glycolic acid) (PLGA‐PEG‐PLGA) triblock copolymers exhibit a sol–gel transition upon heating. The effect of PLGA block and PEG chain molecular weights (MWs) on the gelling temperature of polymer aqueous solution (20% w/w) is described. All polymer solutions convert into a hard gel within 2 °C of the gelling temperature. The release properties of the gels were displayed using paracetamol as a representative drug. A linear relation is described between the gelling temperature and PLGA block MW. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 35–39
Agid:
6260575