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NHERF1 in Microvilli of Vomeronasal Sensory Neurons
- Henkel, Bastian, Bintig, Willem, Bhat, S. Sneha, Spehr, Marc, Neuhaus, Eva M.
- Chemical senses 2017 v.42 no.1 pp. 25-35
- G-protein coupled receptors, mammals, microvilli, scaffolding proteins, sensory neurons, sexual behavior, signal transduction, sodium-hydrogen antiporter
- In most mammals, the vomeronasal system detects a variety of (semio)chemicals that mediate olfactory-driven social and sexual behaviors. Vomeronasal chemosensation depends on G protein-coupled receptors (V1R, V2R, and FPR-rs) that operate at remarkably low stimulus concentrations, thus, indicating a highly sensitive and efficient signaling pathway. We identified the PDZ domain-containing protein, Na⁺/H⁺ exchanger regulatory factor-1 (NHERF1), as putative molecular organizer of signal transduction in vomeronasal neurons. NHERF1 is a protein that contains 2 PDZ domains and a carboxy-terminal ezrin-binding domain. It localizes to microvilli of vomeronasal sensory neurons and interacts with V1Rs. Furthermore, NHERF1 and Gαᵢ₂ are closely colocalized. These findings open up new aspects of the functional organization and regulation of vomeronasal signal transduction by PDZ scaffolding proteins.