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Selective Catalytic Formation of Cross-Tetramers from Tetrafluoroethylene, Ethylene, Alkynes, and Aldehydes via Nickelacycles as Key Reaction Intermediates
- Kawashima, Takuya, Ohashi, Masato, Ogoshi, Sensuke
- Journal of the American Chemical Society 2018 v.140 no.50 pp. 17423-17427
- aldehydes, alkynes, ethylene, nickel, stoichiometry
- In the presence of a catalytic amount of Ni(cod)₂ (cod = 1,5-cyclooctadiene) and PCy₃ (Cy = cyclohexyl), the cross-tetramerization of tetrafluoroethylene (TFE), ethylene, alkynes, and aldehydes leads to a variety of fluorine-containing enone derivatives. This reaction is the first example of a highly selective cross-tetramerization between four different unsaturated compounds. Stoichiometric reactions revealed that the present reaction involves partially fluorinated five- and seven-membered nickelacycles as key reaction intermediates.