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Pharmacokinetics of Bedrocan®, a cannabis oil extract, in fasting and fed dogs: An explorative study
- Łebkowska-Wieruszewska, Beata, Stefanelli, Fabio, Chericoni, Silvio, Owen, Helen, Poapolathep, Amnart, Lisowski, Andrzej, Giorgi, Mario
- Research in veterinary science 2019 v.123 pp. 26-28
- absorption, active ingredients, bioavailability, blood, cannabidiol, dogs, experimental design, oils, pharmacokinetics
- The aim of this study was to explore the pharmacokinetics of the two main active compounds (THC and CBD) contained in the cannabis oil extract Bedrocan® in fasting and fed dogs. Bedrocan® (20% delta-9-tetrahydrocannabinol [THC] and 0.5% cannabidiol [CBD]) was administered at 1.5 and 0.037 mg/kg THC and CBD, respectively in fasted and fed dogs according to a 2 × 2 cross over study design. The quantification of the two active ingredients was performed by LC/MS. No detectable concentrations of CDB were found at any collection time. THC was quantifiable from 0.5 to 10 h, although there was large inter-subject variability. Fed dogs showed a longer absorption phase (Tmax 5 vs 1.25 h) and lower maximal blood concentration (7.1 vs 24 ng/mL) compared with the fasted group. A larger AUC was found in the fasted group; the relative oral bioavailability in fed animals was 48.22%.