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Food advanced glycation end products as potential endocrine disruptors: An emerging threat to contemporary and future generation

Ravichandran, Guna, Lakshmanan, Dinesh Kumar, Raju, Karthik, Elangovan, Abbirami, Nambirajan, Gayathri, Devanesan, Arul Ananth, Thilagar, Sivasudha
Environment international 2019 v.123 pp. 486-500
advanced glycation end products, diabetes, endocrine system, endocrine-disrupting chemicals, glycation, growth and development, hormones, humans, manufacturing, metabolism, neoplasms, oxidative stress, processed foods, society, taste, temperature, tissues, wildlife
Mankind exposure to chemicals in the past century has increased dramatically throughout environment. There is no question that chemicals interfere with the physiology of biological system. Abundance of chemicals is documented to be detrimental to human and wildlife. The mammalian endocrine system is comprised of many interacting tissues mediate themselves through hormones that are essential for metabolism, growth and development. Humans secrete over fifty different hormones to orchestrate major physiological functions however; these vital functions can be intervened by huge number of internal and external chemical stressors that are identified as endocrine disruptors. Advanced glycation end products (AGEs), familiarly known as Maillard products, formed through non-enzymatic glycation whose production is augmented on aging as well as environmental stressors. Processed foods have become very popular today due to their taste, convenience, and inexpensiveness. Manufacture of these day-to-day foods involves extreme temperatures on processing results in the formation of AGEs could independently promote oxidative stress, aging, diabetes, cancer, degenerative diseases, more fascinatingly hormonal disruption is the subject of interest of this review. Based on some substantial observations documented till time, we discuss the emergence of dietary AGEs as potential endocrine disruptors by emphasizing their occurrence, mechanisms and participation in endocrine interruption. Both economically and in terms of human life, AGEs may represent an enormous cost for the future society. Therefore, by explicating their novel role in endocrine diseases, the review strives to make an impact on AGEs and their exposure among public as well as scientific communities.