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A single-atom Fe–N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection

Author:
MaThese authors contributed equally to this work., Wenjie, Mao, Junjie, Yang, Xiaoti, Pan, Cong, Chen, Wenxing, Wang, Ming, Yu, Ping, Mao, Lanqun, Li, Yadong
Source:
Chemical communications 2018 v.55 no.2 pp. 159-162
ISSN:
1364-548X
Subject:
active sites, carbon, catalase, chemical compounds, chemical reactions, oxidative stress, reactive oxygen species, superoxide dismutase
Abstract:
Atomically dispersed Fe–N₄ sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells.
Agid:
6266307