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Search for Correlation between Indicators of Tolerance to Extreme Impacts and Levels of Individual Heterozygosity

Kurbatova, O. L., Pobedonostseva, E. Yu., Kaspransky, R. R., Larina, O. N.
Russian journal of genetics 2018 v.54 no.12 pp. 1471-1478
correspondence analysis, genetic markers, heterozygosity, space flight
This paper presents the results of studying the problem of differential adaptation of genotypes to the extreme conditions of spaceflights. Analysis of the statistical correlations between the integral parameters of the genotype and indicators of endurance against the effects of spaceflight factors (SFFs) was carried out in the cohort of the Russian cosmonauts. The relevance of this study is related to the need to substantiate the possibility, validity, and prospects of using genetic tests to predict individual resistance to SFFs. Various methods of correlation analysis and the method of correspondence analysis were applied. With the help of traditional methods of correlation analysis, weak but statistically significant correlation was revealed between the parameter of individual heterozygosity and indicators of vestibular resistance, as well as with the total indicator of resistance to simulated SFFs. Correspondence analysis confirmed the existence of such associations. The results of the study indicate the need to increase the sample size and to attract a wide range of genetic markers for a statistically significant substantiation of correlation between the indicators of resistance against SFFs and the integral parameters of the genotype.