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Polyphenolic composition, antioxidant and antiproliferative effects of wild and cultivated blackberries (Rubus fruticosus L.) pomace

Author:
Jazić, Miodrag, Kukrić, Zoran, Vulić, Jelena, Četojević‐Simin, Dragana
Source:
International journal of food science & technology 2019 v.54 no.1 pp. 194-201
ISSN:
0950-5423
Subject:
Rubus plicatus, adenocarcinoma, anthocyanins, antioxidant activity, antioxidants, blackberries, breasts, cell lines, flavonols, free radicals, functional foods, neoplasm cells, polyphenols, pomace, pomace extracts, uterine cervical neoplasms, value added
Abstract:
The content of total polyphenolics, antioxidative capacity and antiproliferative activity were tested in wild and cultivated blackberry pomace. Wild blackberry pomace extract Tw2 showed the highest following contents: total polyphenolics (50.16 mg GAE g⁻¹ dw), flavonoids (7.73 mg Qc g⁻¹ dw), flavonols (6.63 mg Qc g⁻¹ dw) and total monomeric anthocyanins (13.40 mg Cy g⁻¹). Tw2 extract significantly inhibited free radicals: IC₅₀ᴰᴾᴾᴴ = 127.76 μg mL⁻¹, IC₅₀ᴬᴮᵀS = 26.53 μg mL⁻¹ and IC₅₀˙ᴼᴴ = 168.62 μg mL⁻¹, and the growth of breast adenocarcinoma IC₅₀ᴹCF⁷ = 306.68 μg mL⁻¹ and cervix epitheloid carcinoma cell lines IC₅₀ᴴᵉᴸᵃ = 315.49 μg mL⁻¹. Wild blackberry varieties had higher extraction yields, higher total polyphenolic contents and possessed stronger biological effects compared to cultivated blackberries (P < 0.05). All blackberry extracts showed high biological potential that could be attributed to high total polyphenols and flavonoids content and could be utilised as value‐added functional food.
Agid:
6268070