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AgSbF₆-Catalyzed anti-Markovnikov hydroboration of terminal alkynes

Author:
MamidalaR. Mamidala and V. K. Pandey contributed equally., Ramesh, Pandey, Vipin K., Rit, Arnab
Source:
Chemical communications 2019 v.55 no.7 pp. 989-992
ISSN:
1364-548X
Subject:
alkynes, ambient temperature, chemical reactions
Abstract:
AgSbF₆-Catalyzed anti-Markovnikov addition of pinacolborane (HBpin) to terminal alkynes to produce the E-vinylboronates is reported. This efficient methodology is scalable, compatible with sterically and electronically diverse alkynes, and works at room temperature under solvent-free condition. The utility of this method is demonstrated in the facile synthesis of the clinically important (E)-2,4,3′,5′-tetramethoxystilbene.
Agid:
6269108