PubAg

Main content area

Regioselective 5′-position phosphorylation of ribose and ribonucleosides: phosphate transfer in the activated pyrophosphate complex in the gas phase

Author:
HuThese authors contributed equally., Jun, Lei, Wen, Wang, Jiang, Chen, Hong-Yuan, Xu, Jing-Juan
Source:
Chemical communications 2019 v.55 no.3 pp. 310-313
ISSN:
1364-548X
Subject:
gases, ionization, phosphates, phosphorylation, regioselectivity, ribonucleosides, ribose
Abstract:
Herein, we present a rapid, efficient and regioselective phosphorylation method at the 5′-position of unprotected ribose and ribonucleosides with pyrophosphate in the gas phase, which involves the formation of anionic complexes via electrospray ionization and collisional activation to induce phosphorylation within the complexes.
Agid:
6269176