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Selenols: a new class of carbonic anhydrase inhibitors

Author:
AngeliThese authors contributed equally to this work., Andrea, Tanini, Damiano, Nocentini, Alessio, Capperucci, Antonella, Ferraroni, Marta, Gratteri, Paola, Supuran, Claudiu T.
Source:
Chemical communications 2019 v.55 no.5 pp. 648-651
ISSN:
1364-548X
Subject:
X-ray diffraction, carbonate dehydratase, chemical compounds, chemical reactions, chemotypes, enzyme inhibitors, humans
Abstract:
Stable aryl selenols were obtained through a convenient procedure. Selenols represent a new chemotype acting as carbonic anhydrase inhibitors (CAIs), inhibiting four human isoforms, CAs I, II, VII and the tumor-associated CA IX. X-ray crystallographic, physical and computational studies provided insights into the binding mode of this conceptually new class of CAIs.
Agid:
6269182